Rodents are famous for their teeth. The large, paired cutting teeth (incisors) in the front of their mouth give them a buck-toothed appearance. The incisors are self-sharpening, thanks to the way they grind together during gnawing. While a strong enamel coating prevents wear on the front, the back of each incisor is soft and wears down. The outcome is a chisel-like shape that can cut into wood, food, or predators. The incisors grow continuously, creating tooth material for sharpening throughout the life of a rodent. A rodent skull is shaped to support the muscles used in gnawing, such as an enlarged region (the pterygoid) that anchors the lower jaw muscles. A skull modification allows the lower jaw to move not only up and down, but back and forth for better grinding action. Rodents are the largest group of mammals on Earth, and their ability to gnaw is part of the reason they have been so successful.

Mammals have a unique arrangement of a lower jaw directly hinged to the skull. The upper jaw is fixed, while the lower jaw is movable. A powerful bite results which, coupled with specialized teeth, allows mammals to eat a diversity of foods. Straight-edged incisor teeth at the front of the jaw are for cutting and gnawing. Pointed, canine teeth on the sides can grab and tear meat. Flat, broad molars are used to grind or crush plants or shelled animals. Mammals tend to have more than one type of tooth (heterodont dentition), with the mix depending on diet. Meat-eaters have sharp incisors and canines plus slicing molars; mammals who eat tough plants have duller incisors and canines, but large, ridged molars. All types of mammal teeth are replaced once or never during a mammal's lifetime. A coating of enamel, the hardest material found in a mammal's body, makes teeth built to last.