Mammals are named for their special milk-producing structures called mammary glands. A female mammal may have two (like humans) or as many as 18 mammary glands. Each gland is full of small spaces lined with milk-secreting cells that all drain into a nipple. Newborn mammals have an innate sucking reflex that stimulates the mother's mammary glands to release milk. Milk is a superfood for young mammals, containing a nourishing mix of fats, proteins, vitamins, minerals, and even immune-system chemicals. The first milk (colostrum) contains antibodies from the mother to protect against disease. As the offspring grows, milk changes to maintain the right balance of nutrients. Production of milk (lactation) makes most female mammals temporarily unable to get pregnant, resulting in natural gaps between offspring. The spacing of births benefits both the offspring and the mother in terms of survival. Mother mammals stop nursing (wean) their babies after several days or years, depending on the species and environmental conditions.

All mammals have hair, outgrowths of the skin, during at least some part of their development. While it evolved to insulate animals in cold climates, mammal hair has various functions. Long, stiff hairs (vibrissae, or whiskers) are found in all mammals but humans. Whether on the face, legs, or tail, vibrissae extend an animal's sense of touch. Some mammals, such as porcupines, have enlarged hairs that function as defensive spines. Defense is also achieved by raising individual hairs to make an animal look larger (such as an angry cat). Muscles in the skin make the hair stand up or lie down. Raising and lowering hair changes how much air is trapped under it, which also makes it more or less insulating. Mammals in cold climates tend to have an extra layer of insulating fur, or extra fat under their fur. Mammals in climates that change seasonally shed and replace their hair to create a thicker winter coat and a thinner summer coat.